Pycnalin, a new α-glucosidase inhibitor from Acer pycnanthum

Ai Ogawa, Yusaku Miyamae, Atsushi Honma, Tomoyuki Koyama, Kazunaga Yazawa, Hideyuki Shigemori*

*この研究の対応する著者

研究成果: Article査読

13 被引用数 (Scopus)

抄録

A new compound, pycnalin (1), together with four known compounds, ginnalins A (2), B (3), C (4), and 3,6-di-O-galloyl-1,5-anhydro-D-glucitol (3,6-di-GAG) (5), were isolated from Acer pycnanthum. The structure of 1 was determined on the basis of 2D-NMR spectral data and synthesis of 1. Pycnalin (1) is the first 1,5-anhydro-D-mannitol linked to a gallic acid, while compounds 2-5 were 1,5-anhydro-D-glucitol linked to gallic acids. All compounds were tested in vitro for α-glucosidase inhibitory and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. Pycnalin (1) exhibited moderate α-glucosidase inhibitory activity as well as free radical scavenging activity. Ginnalin A (2) and 3,6-di-GAG (5), which have two galloyl groups, exhibited potent α-glucosidase inhibition, compared to those of other compounds 1, 3, and 4 containing a galloyl group. These results suggest that α-glucosidase inhibition is influenced by the number of galloyl groups.

本文言語English
ページ(範囲)672-675
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
59
5
DOI
出版ステータスPublished - 2011 5月
外部発表はい

ASJC Scopus subject areas

  • 創薬
  • 化学 (全般)

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