Quantitative evaluation of cell-to-cell communication effects in cell group class using on-chip individual-cell-based cultivation system

Yuichi Wakamoto, Kenji Yasuda

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Cell-to-cell communication is considered to underlie the coordinated behavior and the multicellularity of cell group class, which cannot be explained only by the knowledge of lower class of life system from molecule to individual cell, because they are determined by at least two different ways: diffusible chemical signals and their direct physical contacts. We show in this paper a new method of individual-cell-based cell observation that can estimate the role of cell-to-cell communication, diffusible chemical signals, and physical contacts as separated properties, by applying an on-chip individual-cell-based cultivation system. The exchange of stationary phase medium on isolated individual Escherichia coli from exponential phase medium and the control of physical contacts indicated that the cell-to-cell direct contact did not affect the growth rate; only the communication through diffusible signals affects the growth rates as Hill's equation manner.

本文言語English
ページ(範囲)1130-1138
ページ数9
ジャーナルBiochemical and Biophysical Research Communications
349
3
DOI
出版ステータスPublished - 2006 10 27
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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