Quantitative evaluation of closed-loop-shaped cardiomyocyte network by using ring-shaped electrode

Fumimasa Nomura*, Tomoyuki Kaneko, Tomoyo Hamada, Akihiro Hattori, Kenji Yasuda

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Re-entry of excitation in the heart is one of the abnormal phenomena that causes lethal arrhythmia and is thought to be induced by the looped structure of the excitation conduction pathway. To evaluate the geometrical pattern dependence of electrophysiological results, we fabricated three models of cardiomyocyte networks and compared their beating frequencies (BFs), amplitudes of a depolarization peak, and field potential durations (FPDs). The set of different closed-loop-shaped network models from 3 to 8mm in length showed the same BFs, amplitudes, and FPDs independent of their loop lengths, whereas the BFs and FPDs of 60 μm small clusters, and the FPDs of the 2mm open-line-shaped network model were different from those of a closed-loop-shaped network model. These results indicate that the mm order larger size of clusters might create lower BFs, and the closed-loop-shaped model may generate longer FPDs. They also suggest the importance of spatial arrangement control of the cardoimyocyte community for reproducible measurement of electrophysiological properties of cardiomyocytes, especially control of the closedloop formation, which might change the waveforms of FPDs depending on the difference in the geometry and conduction pathway of the cell network.

本文言語English
論文番号06FK06
ジャーナルJapanese journal of applied physics
51
6 PART 2
DOI
出版ステータスPublished - 2012 6月
外部発表はい

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(全般)

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