Quantum dots induce heat shock-related cytotoxicity at intracellular environment

Satoshi Migita*, Alexandre Moquin, Hitomi Fujishiro, Seiichiro Himeno, Dusica Maysinger, Françoise M. Winnik, Akiyoshi Taniguchi

*この研究の対応する著者

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Quantum dots (QDs) are semiconductor nanocrystals with unique optical properties. Different proteins or polymers are commonly bound to their surfaces to improve biocompatibility. However, such surface modifications may not provide sufficient protection from cytotoxicity due to photodegradation and oxidative degradation. In this study, the cytotoxic effects of QDs, CdTe, and CdSe/ZnS were investigated using cadmium-resistant cells. CdTe QDs significantly reduced cell viability, whereas, CdSe/ZnS treatment did not markedly decrease the cell number. CdTe QDs were cytotoxic in cadmium-resistant cells suggesting that internalized QDs degraded and cadmium ions contributed to the cytotoxic effects. CdTe QDs were consistently more cytotoxic than CdSe/ZnS QDs, but both QDs as well as cadmium ions activated heat shock protein 70B' promoter. QDs themselves are likely to contribute to HSP70B' promoter activation in cadmium-resistant cells, because CdSe/ZnS QDs do not release sufficient cadmium to activate this promoter.

本文言語English
ページ(範囲)367-372
ページ数6
ジャーナルIn Vitro Cellular and Developmental Biology - Animal
50
4
DOI
出版ステータスPublished - 2014 4月
外部発表はい

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学

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