RAFT polymerization of temperature- and salt-responsive block copolymers as reversible hydrogels

Sean T. Hemp, Adam E. Smith, W. Clayton Bunyard, Michael H. Rubinstein, Timothy Edward Long

研究成果: Article

14 引用 (Scopus)

抄録

Reversible-addition fragmentation chain transfer (RAFT) polymerization enabled the synthesis of novel, stimuli-responsive, AB and ABA block copolymers. The B block contained oligo(ethylene glycol) methyl ether methacrylate (OEG) and was permanently hydrophilic in the conditions examined. The A block consisted of diethylene glycol methyl ether methacrylate (DEG) and [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMA). The A block displayed both salt- and temperature-response with lower critical solution temperatures (LCSTs) dependent on the molar content of TMA and the presence of salt. Higher TMA content in the AB diblock copolymers increased the critical micelle temperatures (CMT) in HPLC-grade water due to an increased hydrophilicity of the A block. Upon addition of 0.9 wt% NaCl, the CMTs of poly(OEG-b-DEG95TMA5) decreased from 50 °C to 36 °C due to screening of electrostatic repulsion between the TMA units. ABA triblock copolymers displayed excellent hydrogel properties with salt- and temperature-dependent gel points. TMA incorporation in the A block increased the gel points for all triblock copolymers, and salt-response increased with higher TMA composition in the A block. For example, poly(DEG98TMA 2-b-OEG-b-DEG98TMA2) formed a hydrogel at 40 °C in HPLC-grade water and 26 °C in 0.9 wt% NaCl aqueous solution. These salt- and temperature-responsive AB diblock and ABA triblock copolymers find applications as drug delivery vehicles, adhesives, and hydrogels.

元の言語English
ページ(範囲)2325-2331
ページ数7
ジャーナルPolymer (United Kingdom)
55
発行部数10
DOI
出版物ステータスPublished - 2014 5 13
外部発表Yes

Fingerprint

Hydrogels
Block copolymers
Chlorides
Salts
Polymerization
Methyl Ethers
Methacrylates
Hydrogel
Ethers
Gels
Temperature
Ethylene Glycol
Water
Hydrophilicity
Micelles
Glycols
Ethylene glycol
Drug delivery
Electrostatics
Adhesives

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

これを引用

RAFT polymerization of temperature- and salt-responsive block copolymers as reversible hydrogels. / Hemp, Sean T.; Smith, Adam E.; Bunyard, W. Clayton; Rubinstein, Michael H.; Long, Timothy Edward.

:: Polymer (United Kingdom), 巻 55, 番号 10, 13.05.2014, p. 2325-2331.

研究成果: Article

Hemp, Sean T. ; Smith, Adam E. ; Bunyard, W. Clayton ; Rubinstein, Michael H. ; Long, Timothy Edward. / RAFT polymerization of temperature- and salt-responsive block copolymers as reversible hydrogels. :: Polymer (United Kingdom). 2014 ; 巻 55, 番号 10. pp. 2325-2331.
@article{b7fa813ee3cc46b7a405759d94f8771c,
title = "RAFT polymerization of temperature- and salt-responsive block copolymers as reversible hydrogels",
abstract = "Reversible-addition fragmentation chain transfer (RAFT) polymerization enabled the synthesis of novel, stimuli-responsive, AB and ABA block copolymers. The B block contained oligo(ethylene glycol) methyl ether methacrylate (OEG) and was permanently hydrophilic in the conditions examined. The A block consisted of diethylene glycol methyl ether methacrylate (DEG) and [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMA). The A block displayed both salt- and temperature-response with lower critical solution temperatures (LCSTs) dependent on the molar content of TMA and the presence of salt. Higher TMA content in the AB diblock copolymers increased the critical micelle temperatures (CMT) in HPLC-grade water due to an increased hydrophilicity of the A block. Upon addition of 0.9 wt{\%} NaCl, the CMTs of poly(OEG-b-DEG95TMA5) decreased from 50 °C to 36 °C due to screening of electrostatic repulsion between the TMA units. ABA triblock copolymers displayed excellent hydrogel properties with salt- and temperature-dependent gel points. TMA incorporation in the A block increased the gel points for all triblock copolymers, and salt-response increased with higher TMA composition in the A block. For example, poly(DEG98TMA 2-b-OEG-b-DEG98TMA2) formed a hydrogel at 40 °C in HPLC-grade water and 26 °C in 0.9 wt{\%} NaCl aqueous solution. These salt- and temperature-responsive AB diblock and ABA triblock copolymers find applications as drug delivery vehicles, adhesives, and hydrogels.",
keywords = "Hydrogels, RAFT polymerization, Stimuli-responsive",
author = "Hemp, {Sean T.} and Smith, {Adam E.} and Bunyard, {W. Clayton} and Rubinstein, {Michael H.} and Long, {Timothy Edward}",
year = "2014",
month = "5",
day = "13",
doi = "10.1016/j.polymer.2014.03.062",
language = "English",
volume = "55",
pages = "2325--2331",
journal = "Polymer (United Kingdom)",
issn = "0032-3861",
publisher = "Elsevier BV",
number = "10",

}

TY - JOUR

T1 - RAFT polymerization of temperature- and salt-responsive block copolymers as reversible hydrogels

AU - Hemp, Sean T.

AU - Smith, Adam E.

AU - Bunyard, W. Clayton

AU - Rubinstein, Michael H.

AU - Long, Timothy Edward

PY - 2014/5/13

Y1 - 2014/5/13

N2 - Reversible-addition fragmentation chain transfer (RAFT) polymerization enabled the synthesis of novel, stimuli-responsive, AB and ABA block copolymers. The B block contained oligo(ethylene glycol) methyl ether methacrylate (OEG) and was permanently hydrophilic in the conditions examined. The A block consisted of diethylene glycol methyl ether methacrylate (DEG) and [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMA). The A block displayed both salt- and temperature-response with lower critical solution temperatures (LCSTs) dependent on the molar content of TMA and the presence of salt. Higher TMA content in the AB diblock copolymers increased the critical micelle temperatures (CMT) in HPLC-grade water due to an increased hydrophilicity of the A block. Upon addition of 0.9 wt% NaCl, the CMTs of poly(OEG-b-DEG95TMA5) decreased from 50 °C to 36 °C due to screening of electrostatic repulsion between the TMA units. ABA triblock copolymers displayed excellent hydrogel properties with salt- and temperature-dependent gel points. TMA incorporation in the A block increased the gel points for all triblock copolymers, and salt-response increased with higher TMA composition in the A block. For example, poly(DEG98TMA 2-b-OEG-b-DEG98TMA2) formed a hydrogel at 40 °C in HPLC-grade water and 26 °C in 0.9 wt% NaCl aqueous solution. These salt- and temperature-responsive AB diblock and ABA triblock copolymers find applications as drug delivery vehicles, adhesives, and hydrogels.

AB - Reversible-addition fragmentation chain transfer (RAFT) polymerization enabled the synthesis of novel, stimuli-responsive, AB and ABA block copolymers. The B block contained oligo(ethylene glycol) methyl ether methacrylate (OEG) and was permanently hydrophilic in the conditions examined. The A block consisted of diethylene glycol methyl ether methacrylate (DEG) and [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMA). The A block displayed both salt- and temperature-response with lower critical solution temperatures (LCSTs) dependent on the molar content of TMA and the presence of salt. Higher TMA content in the AB diblock copolymers increased the critical micelle temperatures (CMT) in HPLC-grade water due to an increased hydrophilicity of the A block. Upon addition of 0.9 wt% NaCl, the CMTs of poly(OEG-b-DEG95TMA5) decreased from 50 °C to 36 °C due to screening of electrostatic repulsion between the TMA units. ABA triblock copolymers displayed excellent hydrogel properties with salt- and temperature-dependent gel points. TMA incorporation in the A block increased the gel points for all triblock copolymers, and salt-response increased with higher TMA composition in the A block. For example, poly(DEG98TMA 2-b-OEG-b-DEG98TMA2) formed a hydrogel at 40 °C in HPLC-grade water and 26 °C in 0.9 wt% NaCl aqueous solution. These salt- and temperature-responsive AB diblock and ABA triblock copolymers find applications as drug delivery vehicles, adhesives, and hydrogels.

KW - Hydrogels

KW - RAFT polymerization

KW - Stimuli-responsive

UR - http://www.scopus.com/inward/record.url?scp=84899975860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899975860&partnerID=8YFLogxK

U2 - 10.1016/j.polymer.2014.03.062

DO - 10.1016/j.polymer.2014.03.062

M3 - Article

AN - SCOPUS:84899975860

VL - 55

SP - 2325

EP - 2331

JO - Polymer (United Kingdom)

JF - Polymer (United Kingdom)

SN - 0032-3861

IS - 10

ER -