Rapid quantitative method for the detection of phenylalanine and tyrosine in human plasma using pillar array columns and gradient elution

Yanting Song, Katsuya Takatsuki, Tetsushi Sekiguchi, Takashi Funatsu, Shuichi Shoji, Makoto Tsunoda*

*この研究の対応する著者

研究成果: Article査読

16 被引用数 (Scopus)

抄録

This study reports a fast and quantitative determination method for phenylalanine (Phe) and tyrosine (Tyr) in human plasma using on-chip pressure-driven liquid chromatography. A pillar array column with low-dispersion turns and a gradient elution system was used. The separation of fluorescent derivatives of Phe, Tyr, and other hydrophobic amino acids was successfully performed within 140 s. Under the optimized conditions, Phe and Tyr in human plasma were quantified. The developed method is promising for rapid diagnosis in the clinical field.

本文言語English
ページ(範囲)1731-1735
ページ数5
ジャーナルAmino Acids
48
7
DOI
出版ステータスPublished - 2016 7 1

ASJC Scopus subject areas

  • 生化学
  • 臨床生化学
  • 有機化学

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