Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads

George E. Bentley, Kazuyoshi Tsutsui, Lance J. Kriegsfeld

    研究成果: Article査読

    64 被引用数 (Scopus)

    抄録

    The hypothalamo-pituitary-gonadal (HPG) axis integrates internal and external cues via a balance of stimulatory and inhibitory neurochemical systems to time reproductive activity. The cumulative output of these positive and negative modulators drives secretion of gonadotropin-releasing hormone (GnRH), a neuropeptide that causes pituitary gonadotropin synthesis and secretion. Ten years ago, Tsutsui and colleagues discovered a peptide in quail hypothalamus that is capable of inhibiting gonadotropin secretion in cultured quail pituitary cells. Later studies by a variety of researchers examined the presence and functional role for the mammalian ortholog of GnIH. To date, GnIH exhibits a similar distribution and functional role in all mammals investigated, including humans. This overview summarizes the role of GnIH in modulation of mammalian reproductive physiology and suggests avenues for further study by those interested in the neuroendocrine control of reproductive physiology and sexual behavior.

    本文言語English
    ページ(範囲)62-71
    ページ数10
    ジャーナルBrain Research
    1364
    DOI
    出版ステータスPublished - 2010 12月 10

    ASJC Scopus subject areas

    • 神経科学(全般)
    • 臨床神経学
    • 発生生物学
    • 分子生物学

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