Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis

Toru Ishikawa, Takafumi Ichida, Yasunobu Matsuda, Soichi Sugitani, Motoya Sugiyama, Takashi Kato, Hiroshi Miyazaki, Hitoshi Asakura

研究成果: Article

56 引用 (Scopus)

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It is widely accepted that thrombocytopenia associated with liver cirrhosis is caused by increased platelet destruction in the enlarged spleen, but this issue has not yet been analysed sufficiently in terms of platelet production. Thrombopoietin is produced mainly in the liver and strongly promotes platelet production. We studied serum thrombopoietin and the levels of its mRNA in liver tissue of cirrhotic patients and also in a rat model of liver cirrhosis. Furthermore, to clarify the influence of the spleen, we investigated thrombopoietin mRNA in splenectomized rats. The serum thrombopoietin level in humans with liver cirrhosis was not significantly reduced instead of thrombocytopenia. The expression of thrombopoietin mRNA in liver tissue decreased with the progression of liver cirrhosis in both patients and the rat model and no compensatory expression was observed in other organs or nonparenchymal cells. The level of thrombopoietin mRNA did not differ significantly in splenectomized cirrhotic rats before or after administration of dimethylnitrosamine, but was lower than that in splenectomized rats without cirrhosis. We conclude that thrombocytopenia in liver cirrhosis is caused not only by platelet destruction but also by decreased platelet production, perhaps due to reduction of thrombopoietin mRNA in the liver.

元の言語English
ページ(範囲)907-913
ページ数7
ジャーナルJournal of Gastroenterology and Hepatology (Australia)
13
発行部数9
DOI
出版物ステータスPublished - 1998

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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