Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences

Kazuhiro Furukawa*, Hiroshi Abe, Jin Wang, Miwako Uda, Hiroyuki Koshino, Satoshi Tsuneda, Yoshihiro Ito

*この研究の対応する著者

研究成果: Article査読

39 被引用数 (Scopus)

抄録

We have developed a new red fluorogenic compound derived from naphthorhodamine for a reduction-triggered fluorescence probe to sense oligonucleotides. The fluorogenic reaction between naphthorhodamine azide derivatives and reducing reagents such as triphenylphosphine (TPP) on the DNA target does not use any enzyme or reagent, and fluoresces at 650 nm. The probes were used for dual color detection of a single nucleotide difference on the leukemia-related bcr/abl gene.

本文言語English
ページ(範囲)671-677
ページ数7
ジャーナルOrganic and Biomolecular Chemistry
7
4
DOI
出版ステータスPublished - 2009 2月 16

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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