Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences

Kazuhiro Furukawa; Hiroshi Abe; Jin Wang; Miwako Uda; Hiroyuki Koshino; Satoshi Tsuneda; Yoshihiro Ito

doi:10.1039/b817228e

Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences

Kazuhiro Furukawa^*, Hiroshi Abe, Jin Wang, Miwako Uda, Hiroyuki Koshino, Satoshi Tsuneda, Yoshihiro Ito

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

41 被引用数 (Scopus)

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We have developed a new red fluorogenic compound derived from naphthorhodamine for a reduction-triggered fluorescence probe to sense oligonucleotides. The fluorogenic reaction between naphthorhodamine azide derivatives and reducing reagents such as triphenylphosphine (TPP) on the DNA target does not use any enzyme or reagent, and fluoresces at 650 nm. The probes were used for dual color detection of a single nucleotide difference on the leukemia-related bcr/abl gene.

本文言語	English
ページ（範囲）	671-677
ページ数	7
ジャーナル	Organic and Biomolecular Chemistry
巻	7
号	4
DOI	https://doi.org/10.1039/b817228e
出版ステータス	Published - 2009 2月 16

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1039/b817228e

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AU - Abe, Hiroshi

AU - Wang, Jin

AU - Uda, Miwako

AU - Koshino, Hiroyuki

AU - Tsuneda, Satoshi

AU - Ito, Yoshihiro

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Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences

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