Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences

Kazuhiro Furukawa, Hiroshi Abe, Jin Wang, Miwako Uda, Hiroyuki Koshino, Satoshi Tsuneda, Yoshihiro Ito

研究成果: Article

37 引用 (Scopus)

抜粋

We have developed a new red fluorogenic compound derived from naphthorhodamine for a reduction-triggered fluorescence probe to sense oligonucleotides. The fluorogenic reaction between naphthorhodamine azide derivatives and reducing reagents such as triphenylphosphine (TPP) on the DNA target does not use any enzyme or reagent, and fluoresces at 650 nm. The probes were used for dual color detection of a single nucleotide difference on the leukemia-related bcr/abl gene.

元の言語English
ページ(範囲)671-677
ページ数7
ジャーナルOrganic and Biomolecular Chemistry
7
発行部数4
DOI
出版物ステータスPublished - 2009 2 16

    フィンガープリント

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

これを引用