Reelin signaling and Cdk5 in the control of neuronal positioning

Toshio Ohshima*, Katsuhiko Mikoshiba

*この研究の対応する著者

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Neuronal positioning is important for higher brain function because it is the architectural basis of the formation of precise synaptic circuits. Analysis of neurological mutant mice has led to dramatic progress in the identification and characterization of molecules important for neuronal positioning in the developing mammalian brain. Among these molecules, identification of signal pathways mediated by Reelin and Cdk5 kinase has provided a conceptual framework for exploring the molecular mechanisms underlying proper neuronal positioning in the developing mammalian brain. Recent evidence has implicated synergism between Reelin signaling and Cdk5 in contributing to the proper positioning of selective neuronal populations.

本文言語English
ページ(範囲)153-166
ページ数14
ジャーナルMolecular Neurobiology
26
2-3
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 神経学
  • 細胞および分子神経科学

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