Reformation of thalidomide from its hydrolysis compound via intramolecular dehydration

Takuya Taniguchi, Miri Nakamura, Koichi Tsutao, Kohei Otogawa, Yoshiyuki Ogino, Toru Asahi*

*この研究の対応する著者

研究成果: Article査読

抄録

Thalidomide, a famous chiral drug, can be hydrolyzed into three different compounds depending on the reaction site of hydrolysis. This work presents the reformation of thalidomide from one of the hydrolysis compounds through an intramolecular dehydration reaction in acetonitrile. The difference of dehydration behavior between hydrolysis compounds was rationalized based on molecular structures: The reformable molecule has the preferable geometric environment for intramolecular dehydration.

本文言語English
ページ(範囲)1388-1391
ページ数4
ジャーナルChemistry Letters
50
7
DOI
出版ステータスPublished - 2021 7

ASJC Scopus subject areas

  • 化学 (全般)

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