Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats

Hideko Nakamoto, Takao Kaneko, Shoichi Tahara, Eri Hayashi, Hisashi Naito, Zsolt Radak, Sataro Goto*

*この研究の対応する著者

研究成果査読

84 被引用数 (Scopus)

抄録

Exercise is often said to increase the generation of reactive oxygen species that are potentially harmful. On the other hand, regular exercise has various health benefits even late in life. The specific aim of this study was to explore effects of regular exercise on oxidative status of DNA in aged animals. We report that 2 months of regular treadmill running of aged rats (21 month old) significantly reduced 8-oxodG content to the level of young adult animals (11 month old) in both nuclear and mitochondrial DNA of the liver. The mitochondrial DNA showed 10-fold higher content of the oxidative lesion than the nuclear DNA. The levels in old animals were 2- and 1.5-fold higher than that in young adults for the nucleus and mitochondria, respectively. The activity of the repair enzyme OGG1 was upregulated significantly in the nucleus but not in mitochondria by the exercise. To our knowledge, this is the first report demonstrating that regular exercise can reduce significantly oxidative damage to both the nuclear and mitochondrial DNA. We suggest that the apparent beneficial outcomes in reducing the DNA damage by regular exercise can be interpreted in terms of hormetic effect by moderate oxidative stress and potential adaptation to stronger stresses.

本文言語English
ページ(範囲)287-295
ページ数9
ジャーナルExperimental Gerontology
42
4
DOI
出版ステータスPublished - 2007 4 1
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 加齢科学
  • 分子生物学
  • 遺伝学
  • 内分泌学
  • 細胞生物学

フィンガープリント

「Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル