Regulation of chromatin structure by curved DNA: How activator binding sites become accessible

Takashi Ohyama*

*この研究の対応する著者

研究成果: Chapter

抄録

A single somatic cell of humans contains DNA fibers of a total length of approximately 2 m, which are compacted, without entanglement, into the nucleus of approximately 1×10-5 m in diameter. To greater or lesser degrees, all organisms compact their DNA. Biologically important DNA regions, such as the origins of DNA replication, regulatory regions of transcription, and recombination loci, must all be compacted. The tightly constrained DNA, however, presents the appropriate environment for replication, transcription, and recombination to take place.

本文言語English
ホスト出版物のタイトルNuclear Dynamics
ホスト出版物のサブタイトルMolecular Biology and Visualization of the Nucleus
出版社Springer Japan
ページ227-238
ページ数12
ISBN(電子版)9784431301301
ISBN(印刷版)4431300546, 9784431300540
DOI
出版ステータスPublished - 2007 1 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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