Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones

Kohtaro Takei, Ryong Moon Shin, Takafumi Inoue, Kunio Kato, Katsuhiko Mikoshiba

研究成果: Article

152 引用 (Scopus)

抜粋

The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R(IP3R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion of internal Ca2+ stores and inhibition of IP3 signaling with drugs inhibited neurite extension. Microinjection of heparin, a competitive IP3R blocker, induced neurite retraction. Acute localized loss of function of IP3R1 in the growth cone induced by chromophore-assisted laser inactivation resulted in growth arrest and neurite retraction. IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth.

元の言語English
ページ(範囲)1705-1708
ページ数4
ジャーナルScience
282
発行部数5394
出版物ステータスPublished - 1998 11 27
外部発表Yes

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ASJC Scopus subject areas

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これを引用

Takei, K., Shin, R. M., Inoue, T., Kato, K., & Mikoshiba, K. (1998). Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Science, 282(5394), 1705-1708.