Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides

Jean Luc Do Rego, Jae Young Seong, Delphine Burel, Jerôme Leprince, David Vaudry, Van Luu-The, Marie Christine Tonon, Kazuyoshi Tsutsui, Georges Pelletier, Hubert Vaudry*

*この研究の対応する著者

    研究成果: Article査読

    25 被引用数 (Scopus)

    抄録

    The enzymatic pathways leading to the synthesis of bioactive steroids in the brain are now almost completely elucidated in various groups of vertebrates and, during the last decade, the neuronal mechanisms involved in the regulation of neurosteroid production have received increasing attention. This report reviews the current knowledge concerning the effects of neurotransmitters, peptide hormones, and neuropeptides on the biosynthesis of neurosteroids. Anatomical studies have been carried out to visualize the neurotransmitteror neuropeptidecontaining fibers contacting steroidsynthesizing neurons as well as the neurotransmitter, peptide hormones, or neuropeptide receptors expressed in these neurons. Biochemical experiments have been conducted to investigate the effects of neurotransmitters, peptide hormones, or neuropeptides on neurosteroid biosynthesis, and to characterize the type of receptors involved. Thus, it has been found that glutamate, acting through kainate and/or AMPA receptors, rapidly inactivates P450arom, and that melatonin produced by the pineal gland and eye inhibits the biosynthesis of 7α-hydroxypregnenolone (7α-OH-Δ5P), while prolactin produced by the adenohypophysis enhances the formation of 7α-OH-Δ5P. It has also been demonstrated that the biosynthesis of neurosteroids is inhibited by GABA, acting through GABAA receptors, and neuropeptide Y, acting through Y1 receptors. In contrast, it has been shown that the octadecaneuropetide ODN, acting through centraltype benzodiazepine receptors, the triakontatetraneuropeptideTTN, acting though peripheraltype benzodiazepine receptors, and vasotocin, acting through V1alike receptors, stimulate the production of neurosteroids. Since neurosteroids are implicated in the control of various neurophysiological and behavioral processes, these data suggest that some of the neurophysiological effects exerted by neurotransmitters and neuropeptides may be mediated via the regulation of neurosteroid production.

    本文言語English
    論文番号Article 4
    ジャーナルFrontiers in Endocrinology
    3
    JAN
    DOI
    出版ステータスPublished - 2012

    ASJC Scopus subject areas

    • 内分泌学、糖尿病および代謝内科学

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