Relationship between flavonoid structure and reactive oxygen species generation upon ultraviolet and X-ray irradiation

Lei Jiang*, Emiko Yanase, Takashi Mori, Kanae Kurata, Michiru Toyama, Ayaka Tsuchiya, Kosei Yamauchi, Tohru Mitsunaga, Hitoshi Iwahashi, Junko Takahashi

*この研究の対応する著者

研究成果: Article査読

3 被引用数 (Scopus)

抄録

In this research, we aimed to reveal structures related to reactive oxygen species (ROS) generation of flavonoids upon ultraviolet (UV) or X-ray irradiation. ROS production of selected flavonoids was studied by using ROS fluorescence probes. We discuss the relationship between the structures of the flavonoids and the generation of three ROSs, superoxide anion radical (O2 •−), hydroxyl radical (OH), and singlet oxygen (1O2). Results showed that 2,3-double bond was an key structure for natural flavonoids to generate O2 •−. We also discuss the effects of the ROS scavenging capacities on ROS generation through oxygen radical absorbance capacity (ORAC) tests. Derivatives of quercetin could produce OH due to differences of ROS scavenging ability. Our results indicated that flavonoids and their derivatives, which were used as antioxidant reagents, can serve as ROS generators upon ultraviolet (UV) or X-ray irradiation.

本文言語English
論文番号112044
ジャーナルJournal of Photochemistry and Photobiology A: Chemistry
384
DOI
出版ステータスPublished - 2019 11月 1
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)
  • 物理学および天文学(全般)

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