In this research, we aimed to reveal structures related to reactive oxygen species (ROS) generation of flavonoids upon ultraviolet (UV) or X-ray irradiation. ROS production of selected flavonoids was studied by using ROS fluorescence probes. We discuss the relationship between the structures of the flavonoids and the generation of three ROSs, superoxide anion radical (O2 •−), hydroxyl radical (•OH), and singlet oxygen (1O2). Results showed that 2,3-double bond was an key structure for natural flavonoids to generate O2 •−. We also discuss the effects of the ROS scavenging capacities on ROS generation through oxygen radical absorbance capacity (ORAC) tests. Derivatives of quercetin could produce •OH due to differences of ROS scavenging ability. Our results indicated that flavonoids and their derivatives, which were used as antioxidant reagents, can serve as ROS generators upon ultraviolet (UV) or X-ray irradiation.
|ジャーナル||Journal of Photochemistry and Photobiology A: Chemistry|
|出版ステータス||Published - 2019 11月 1|
ASJC Scopus subject areas
- 化学 (全般)