Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells

Masataka Uchida, Eri Oyanagi, Motohiko Miyachi, Akira Yamauchi, Hiromi Yano*

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

We investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged myoblasts using in vitro models of muscle injury. We found that: 1) the chemotactic activity of macrophages toward areas of damaged myoblasts might be induced more by live myoblasts than dead ones, 2) the chemotactic activity of macrophages is not due to velocity, but depends on the directionality toward damaged myoblast cells, and 3) macrophage differentiation strongly influence the chemotactic activity toward damaged myoblast cells through the expression of CCR2 and/or F-actin.

本文言語English
ページ(範囲)61-69
ページ数9
ジャーナルJournal of Immunological Methods
393
1-2
DOI
出版ステータスPublished - 2013
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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