Relationship between microtubule network structure and Intracellular transport in cultured endothelial cells affected by shear stress

Susumu Kudo*, Kenji Ikezawa, Mariko Ikeda, Kazuo Tanishita

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Endothelial cells (ECs) that line the inner surface of blood vessels are barriers to the transport of various substances into or from vessel walls, and are continuously exposed to shear stress induced by blood flow in vivo. Shear stress affects the cytoskeleton (e.g., microtubules, microfilaments, intermediate filaments), and affects the transport of macromolecules. Here, the relationship between the microtubule network structure and this transport process for albumin uptake within cultured aortic endothelial cells affected by shear stress was studied. Based on fluorescent images of albumin uptake obtained by using confocal laser scanning microscopy (CLSM), both the microtubule network and albumin uptake in ECs were disrupted by colchicine and were affected by shear stress loading.

本文言語English
ページ(範囲)977-984
ページ数8
ジャーナルJSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing
47
4
DOI
出版ステータスPublished - 2004 12月
外部発表はい

ASJC Scopus subject areas

  • 産業および生産工学
  • 機械工学

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