Remote Asymmetric Bromination Reaction with Vinylketene Silyl N,O-Acetal and Its Application to Total Synthesis of Pellasoren A

Shinji Sekiya, Mao Okumura, Kei Kubota, Tatsuya Nakamura, Daisuke Sekine, Seijiro Hosokawa

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Stereoselective bromination of the E,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary has been achieved and applied to introduction of heteroatom at γ-position of α,β-unsaturated imide. The reactions proceeded in high stereoselectivity. Total synthesis of pellasoren A, an antitumor propionate from the myxobacteriun Sorangium cellulosum, has been accomplished in short steps by this methodology and our method of reduced polypropionate synthesis.

本文言語English
ページ(範囲)2394-2397
ページ数4
ジャーナルOrganic Letters
19
9
DOI
出版ステータスPublished - 2017 5 5

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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