Research on Au(I)-catalyzed ene-yne cycloisomerization for construction of quassinoid scaffold

Yuta Oki, Masahisa Nakada*

*この研究の対応する著者

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Compounds that undergo Au(I)-catalyzed cycloisomerizations affording tetracyclic products that can be converted into compounds with the skeleton of bruceantin are described. The Au(I)-catalyzed cycloisomerizations reported herein are hindered by a 1,3-diaxial interaction between the substituent and the methyl group in the transition state. The use of small substituents was found to increase the yield of the desired product, while the reaction of substrates with large substituents afford undesired constitutional isomers.

本文言語English
ページ(範囲)926-929
ページ数4
ジャーナルTetrahedron Letters
59
10
DOI
出版ステータスPublished - 2018 3月 7

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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