Resistance exercise training reduces plasma endothelin-1 concentration in healthy young humans

Seiji Maeda*, Takashi Miyauchi, Motoyuki Iemitsu, Jun Sugawara, Yoshihiko Nagata, Katsutoshi Goto

*この研究の対応する著者

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Endothelin-1 (ET-1), which is produced by vascular endothelial cells, has potent vasoconstrictor and proliferative activity in vascular smooth muscle cells, and therefore has been implicated in regulation of vascular tonus and progression of atherosclerosis. We recently demonstrated that the plasma ET-1 concentration was significantly decreased by aerobic exercise training in healthy young humans and healthy older humans. However, it is unclear whether the production of ET-1 is altered by resistance exercise training. We measured the plasma ET-1 concentration before and after resistance exercise training in healthy young humans. Six healthy young men (26 ± 1 years old) performed 8 weeks of resistance exercise training (3 days/week). There were no significant differences in body composition, blood pressure, heart rate, and maximal oxygen consumption before and after resistance exercise training. The girths of the arm and thigh significantly increased after resistance exercise training. The maximal muscle powers in the arm and leg increased after resistance exercise training. After resistance exercise training, the plasma concentration of ET-1 significantly decreased. The present study suggested that resistance exercise training, as well as aerobic exercise training, reduces the plasma ET-1 concentration in healthy young humans, and that this reduction in plasma ET-1 concentration may have beneficial effects on the cardiovascular system.

本文言語English
ページ(範囲)S443-S446
ジャーナルJournal of Cardiovascular Pharmacology
44
SUPPL. 1
DOI
出版ステータスPublished - 2004 11月
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 循環器および心血管医学

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