Respiratory flow in a realistic tracheostenosis model

Toshihiro Sera, Sunao Satoh, Hirohisa Horinouchi, Koichi Kobayashi, Kazuo Tanishita

研究成果: Article

16 引用 (Scopus)

抄録

The possible mechanism of wheeze generation in tracheostenosis was identified by measuring inspiratory and expiratory flow in a "morphological and distensible" realistic tracheostenosis model. The shape of the model was based on CT (Computed Tomography) images of a patient that had tracheostenosis. A trachea consists of tracheal cartilage rings and smooth muscle. Spatial variation of wall distensibility was achieved in the model by varying the wall thickness based on the elastic modulus measured in pig air-ways. The spatial variation influenced the flow in the airway and the turbulence production rate decreased faster at smooth muscles. Using the model, we investigated the mechanism of wheeze generation by focusing on the turbulence intensity. The turbulence intensity in expiratory flow was about twice that in inspiratory flow, and larger vortices existed in post-stenosis in expiratory flow, and thus might contribute to wheeze generation.

元の言語English
ページ(範囲)461-471
ページ数11
ジャーナルJournal of Biomechanical Engineering
125
発行部数4
DOI
出版物ステータスPublished - 2003 8
外部発表Yes

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Smooth Muscle
Turbulence
Elastic Modulus
Trachea
Cartilage
Muscle
Pathologic Constriction
Swine
Air
Tomography
Vortex flow
Elastic moduli

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

これを引用

Sera, T., Satoh, S., Horinouchi, H., Kobayashi, K., & Tanishita, K. (2003). Respiratory flow in a realistic tracheostenosis model. Journal of Biomechanical Engineering, 125(4), 461-471. https://doi.org/10.1115/1.1589775

Respiratory flow in a realistic tracheostenosis model. / Sera, Toshihiro; Satoh, Sunao; Horinouchi, Hirohisa; Kobayashi, Koichi; Tanishita, Kazuo.

:: Journal of Biomechanical Engineering, 巻 125, 番号 4, 08.2003, p. 461-471.

研究成果: Article

Sera, T, Satoh, S, Horinouchi, H, Kobayashi, K & Tanishita, K 2003, 'Respiratory flow in a realistic tracheostenosis model', Journal of Biomechanical Engineering, 巻. 125, 番号 4, pp. 461-471. https://doi.org/10.1115/1.1589775
Sera T, Satoh S, Horinouchi H, Kobayashi K, Tanishita K. Respiratory flow in a realistic tracheostenosis model. Journal of Biomechanical Engineering. 2003 8;125(4):461-471. https://doi.org/10.1115/1.1589775
Sera, Toshihiro ; Satoh, Sunao ; Horinouchi, Hirohisa ; Kobayashi, Koichi ; Tanishita, Kazuo. / Respiratory flow in a realistic tracheostenosis model. :: Journal of Biomechanical Engineering. 2003 ; 巻 125, 番号 4. pp. 461-471.
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