Respiratory flow in a realistic tracheostenosis model

Toshihiro Sera*, Sunao Satoh, Hirohisa Horinouchi, Koichi Kobayashi, Kazuo Tanishita

*この研究の対応する著者

研究成果: Article査読

21 被引用数 (Scopus)

抄録

The possible mechanism of wheeze generation in tracheostenosis was identified by measuring inspiratory and expiratory flow in a "morphological and distensible" realistic tracheostenosis model. The shape of the model was based on CT (Computed Tomography) images of a patient that had tracheostenosis. A trachea consists of tracheal cartilage rings and smooth muscle. Spatial variation of wall distensibility was achieved in the model by varying the wall thickness based on the elastic modulus measured in pig air-ways. The spatial variation influenced the flow in the airway and the turbulence production rate decreased faster at smooth muscles. Using the model, we investigated the mechanism of wheeze generation by focusing on the turbulence intensity. The turbulence intensity in expiratory flow was about twice that in inspiratory flow, and larger vortices existed in post-stenosis in expiratory flow, and thus might contribute to wheeze generation.

本文言語English
ページ(範囲)461-471
ページ数11
ジャーナルJournal of Biomechanical Engineering
125
4
DOI
出版ステータスPublished - 2003 8
外部発表はい

ASJC Scopus subject areas

  • 生体医工学
  • 生物理学

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