Review: Neuroestrogen regulation of socio-sexual behavior of males

Takayoshi Ubuka, Kazuyoshi Tsutsui

    研究成果: Article

    19 引用 (Scopus)

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    It is thought that estrogen (neuroestrogen) synthesized by the action of aromatase in the brain from testosterone activates male socio-sexual behaviors, such as aggression and sexual behavior in birds. We recently found that gonadotropin-inhibitory hormone (GnIH), a hypothalamic neuropeptide, inhibits socio-sexual behaviors of male quail by directly activating aromatase and increasing neuroestrogen synthesis in the preoptic area (POA). The POA is thought to be the most critical site of aromatization and neuroestrogen action for the regulation of socio-sexual behavior of male birds. We concluded that GnIH inhibits socio-sexual behaviors of male quail by increasing neuroestrogen concentration beyond its optimal concentration in the brain for expression of socio-sexual behavior. On the other hand, it has been reported that dopamine and glutamate, which stimulate male socio-sexual behavior in birds and mammals, inhibit the activity of aromatase in the POA. Multiple studies also report that the activity of aromatase or neuroestrogen is negatively correlated with changes in male socio-sexual behavior in fish, birds, and mammals including humans. Here, we review previous studies that investigated the role of neuroestrogen in the regulation of male socio-sexual behavior and reconsider the hypothesis that neuroestrogen activates male socio-sexual behavior in vertebrates. It is considered that basal concentration of neuroestrogen is required for the maintenance of male socio-sexual behavior but higher concentration of neuroestrogen may inhibit male socio-sexual behavior.

    元の言語English
    記事番号323
    ジャーナルFrontiers in Neuroscience
    8
    発行部数OCT
    DOI
    出版物ステータスPublished - 2014

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    Sexual Behavior
    Aromatase
    Preoptic Area
    Birds
    Quail
    Gonadotropins
    Mammals
    Hypothalamic Hormones
    Brain
    Neuropeptides
    Aggression
    Vertebrates
    Testosterone
    Glutamic Acid
    Dopamine
    Estrogens
    Fishes
    Maintenance
    Hormones

    ASJC Scopus subject areas

    • Neuroscience(all)

    これを引用

    Review : Neuroestrogen regulation of socio-sexual behavior of males. / Ubuka, Takayoshi; Tsutsui, Kazuyoshi.

    :: Frontiers in Neuroscience, 巻 8, 番号 OCT, 323, 2014.

    研究成果: Article

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