Risk factors for regrowth of intracranial meningiomas after gamma knife radiosurgery: Importance of the histopathological grade and MIB-1 index

K. Nakaya*, M. Chernov, H. Kasuya, M. Izawa, M. Hayashi, K. Kato, O. Kubo, Y. Muragaki, H. Iseki, T. Hori, Y. Okada, K. Takakura

*この研究の対応する著者

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Introduction: The influence of histopathological grade and MIB-1 index of intracranial meningioma on the results of its radiosurgical management is not clear. The objective of the present retrospective study was to make an evaluation of these factors along with an analysis of other variables associated with progression-free survival after gamma knife radiosurgery (GKR). Patients and Methods: Thirty-four intracranial meningiomas with known detailed histopathological diagnosis were analyzed. Tumors of WHO histopathological grades I, II, and III were diagnosed in 24, 3, and 7 cases, respectively. The median MIB-1 index was 1.3% (range: 031.9%). In 14 cases the MIB-1 index was 3.0% and more. In 26 cases the treatment was done at the time of tumor recurrence. Median volume of the neoplasm at the time of GKR was 4.1mL (range: 0.443.1mL). Median marginal dose was 12Gy (range: 819Gy). Median length of follow-up constituted 63 months (range: 19132 months). Results: Actuarial progression-free survival at 1, 3, 5, and 10 years constituted 100, 94, 83, and 58%, respectively. Histopathological grade II or III (p<0.0001), MIB-1 index 3% and more (p=0.0004), and non-skull base location (p=0.0026) of the tumor showed negative associations with progression-free survival in multivariate analyses. Actuarial progression-free survival at 5 years after GKR for benign and non-benign meningiomas constituted 100 and 45%, respectively (p<0.0001). Conclusion: Radiosurgery is a highly effective management option for benign intracranial meningiomas, but growth control of non-benign ones is significantly worse. It requires close neuroradiological follow-up and necessitates the search for modified treatment strategies.

本文言語English
ページ(範囲)216-221
ページ数6
ジャーナルMinimally Invasive Neurosurgery
52
5-6
DOI
出版ステータスPublished - 2009
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 臨床神経学

フィンガープリント

「Risk factors for regrowth of intracranial meningiomas after gamma knife radiosurgery: Importance of the histopathological grade and MIB-1 index」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル