Rna oscillator: Limit cycle oscillations based on artificial biomolecular reactions

Masahiro Takinoue*, Daisuke Kiga, Koh Ichiroh Shohda, Akira Suyama

*この研究の対応する著者

研究成果: Article査読

7 被引用数 (Scopus)

抄録

In recent years, various DNA nanomachines driven by DNA hybridizations have been developed as a remarkable application of DNA computers for nanotechnology. Here, we propose an oscillatory reaction system as a nano-sized nucleic acid engine to control the nanomachines. It utilizes DNA/RNA and their molecular reactions, and is modeled after the circadian rhythm in life systems. The molecular reactions consist of nucleic acid hybridization, RNA transcription, DNA extension, RNA degradation, and uracil-containing DNA degradation. Numerical analyses of rate equations for the reactions demonstrate that oscillatory conditions of the reaction system are determined by the balance between RNA influx into the system and RNA degradation out of the system. The analytical results will provide important information when the oscillator is constructed in in vitro experiments.

本文言語English
ページ(範囲)107-127
ページ数21
ジャーナルNew Generation Computing
27
2
DOI
出版ステータスPublished - 2009 2
外部発表はい

ASJC Scopus subject areas

  • ソフトウェア
  • 理論的コンピュータサイエンス
  • ハードウェアとアーキテクチャ
  • コンピュータ ネットワークおよび通信

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