Rna oscillator: Limit cycle oscillations based on artificial biomolecular reactions

Masahiro Takinoue, Daisuke Kiga, Koh Ichiroh Shohda, Akira Suyama

研究成果: Article

7 引用 (Scopus)

抜粋

In recent years, various DNA nanomachines driven by DNA hybridizations have been developed as a remarkable application of DNA computers for nanotechnology. Here, we propose an oscillatory reaction system as a nano-sized nucleic acid engine to control the nanomachines. It utilizes DNA/RNA and their molecular reactions, and is modeled after the circadian rhythm in life systems. The molecular reactions consist of nucleic acid hybridization, RNA transcription, DNA extension, RNA degradation, and uracil-containing DNA degradation. Numerical analyses of rate equations for the reactions demonstrate that oscillatory conditions of the reaction system are determined by the balance between RNA influx into the system and RNA degradation out of the system. The analytical results will provide important information when the oscillator is constructed in in vitro experiments.

元の言語English
ページ(範囲)107-127
ページ数21
ジャーナルNew Generation Computing
27
発行部数2
DOI
出版物ステータスPublished - 2009 2 1

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ASJC Scopus subject areas

  • Software
  • Theoretical Computer Science
  • Hardware and Architecture
  • Computer Networks and Communications

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