RNase P as hyperprocessing enzyme: A model for formation of a biologically functional tRNA fragment

Yo Kikuchi*

*この研究の対応する著者

研究成果: Article査読

抄録

Hyperprocessing is defined as a further processing of mature RNA that produces another functional RNA. Hyperprocessing occurs in Drosophila cells. In the transposon copia-related retrovirus-like particles of Drosophila, a 39-nucleotide-long fragment from the 5′-region of Drosophila initiator methionine tRNA is used as the primer for copia minus-strand reverse transcription. This primer tRNA fragment is thought to be produced by cleavage within the mature tRNA sequence. We found that the catalytic RNA subunit of RNase P catalyzes this hyperprocessing in vitro and that this cleavage is dependent of the occurrence of an altered conformation of the tRNA substrate. In this review, I will summarize our work from the finding of the functional RNA fragment to the finding of a dynamic tRNA structure

本文言語English
ページ(範囲)171-175
ページ数5
ジャーナルMolecular Biology Reports: An International Journal on Molecular and Cellular Biology
22
2
DOI
出版ステータスPublished - 1995
外部発表はい

ASJC Scopus subject areas

  • 遺伝学
  • 分子生物学

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