Role of cyclin-dependent kinase 5 in capsaicin-induced cough

Junzo Kamei*, Shun suke Hayashi, Yoshiki Takahashi, Chihiro Nozaki

*この研究の対応する著者

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice. Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced coughs in a concentration-dependent manner. Pretreatment with inhaled roscovitine, at a concentration of 3 mM also slightly but significantly inhibited the number of citric acid-induced coughs. The number of capsaicin-induced coughs was significantly reduced when C-fibers were desensitized by the pretreatment with capsaicin. The number of citric acid-induced coughs was slightly but significantly reduced in capsaicin-pretreated mice as compared with that in naive mice. Although the inhalation of roscovitine at a concentration of 3 mM significantly reduced the number of citric acid-induced coughs in naive mice to the level observed in capsaicin-pretreated mice, roscovitine had no effect on the number of citric acid-induced coughs in capsaicin-pretreated mice. These results suggest that Cdk5-dependent factors are involved in C-fiber-mediated cough signaling.

本文言語English
ページ(範囲)181-184
ページ数4
ジャーナルEuropean Journal of Pharmacology
566
1-3
DOI
出版ステータスPublished - 2007 7 2
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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