Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in xenopus embryos

Shoen Kume*, Akira Muto, Takafumi Inoue, Kei Suga, Hideyuki Okano, Katsuhiko Mikoshiba

*この研究の対応する著者

研究成果: Article査読

97 被引用数 (Scopus)

抄録

The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.

本文言語English
ページ(範囲)1940-1943
ページ数4
ジャーナルScience
278
5345
DOI
出版ステータスPublished - 1997 12 12
外部発表はい

ASJC Scopus subject areas

  • 一般

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