Role of the community effect of cardiomyocyte in the entrainment and reestablishment of stable beating rhythms

Kensuke Kojima, Tomoyuki Kaneko, Kenji Yasuda*

*この研究の対応する著者

研究成果: Article査読

53 被引用数 (Scopus)

抄録

To investigate the roles that the community effect and entrainment function of cultured cardiomyocyte play in decreasing beating fluctuation and reestablishing synchronized beating, we developed a single-cell-based two-dimensional network culture assay to measure and compare the dynamics of beating rhythm synchronization of individual cells before and after they form networks. Studying the formation of two-cell networks, we found that their synchronized beating tended to be determined by the cardiomyocyte whose beat rate fluctuated less than that of the other cardiomyocyte. We further found that the strength of this tendency increased with the number of cells in the network. These results indicate that (1) beating fluctuation is one of the important factors influencing the reestablishment of a stable synchronous beating rhythm, (2) the larger networks reduce fluctuation, and (3) the formation of a spatial network can itself stabilize cardiomyocyte beat rates.

本文言語English
ページ(範囲)209-215
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
351
1
DOI
出版ステータスPublished - 2006 12月 8
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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