TY - JOUR
T1 - Roles of A- and D-type K channels in EPSP integration at a model dendrite
AU - Takagi, Hiroshi
AU - Sato, Ryo
AU - Mori, Masaya
AU - Ito, Etsuro
AU - Suzuki, Hideo
N1 - Funding Information:
We thank Dr. Timo Hannay (Nature Japan K.K.) for his critical reading of the manuscript. This work was partly supported by Grants-in-aid (Nos. 0878077 and 09780741) from the Ministry of Education, Science, Sports and Culture of Japan, and grants from the Inamori Foundation and the Narishige Foundation to H.T.
PY - 1998/10/2
Y1 - 1998/10/2
N2 - We examined the roles of A- and D-type K channels in the integration of EPSPs, particularly EPSP reduction, in a model dendrite using a computer simulation program (NEURON), instead of conventional electrophysiological methods which present technical difficulties. We obtained two important results: (1) KD channels play a crucial role in every synaptic input event, and (2) KA channels affect reduction of the second EPSP only when the second synaptic input is applied with a short interval (≤100 ms). These results suggest that KD channels, which have not yet been analyzed experimentally, play a major role in synaptic integration in dendrites by altering their cable properties.
AB - We examined the roles of A- and D-type K channels in the integration of EPSPs, particularly EPSP reduction, in a model dendrite using a computer simulation program (NEURON), instead of conventional electrophysiological methods which present technical difficulties. We obtained two important results: (1) KD channels play a crucial role in every synaptic input event, and (2) KA channels affect reduction of the second EPSP only when the second synaptic input is applied with a short interval (≤100 ms). These results suggest that KD channels, which have not yet been analyzed experimentally, play a major role in synaptic integration in dendrites by altering their cable properties.
KW - Cable theory
KW - Computer simulation
KW - Dendritic Integration
KW - K Channels
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U2 - 10.1016/S0304-3940(98)00679-X
DO - 10.1016/S0304-3940(98)00679-X
M3 - Article
C2 - 10214983
AN - SCOPUS:0032476072
SN - 0304-3940
VL - 254
SP - 165
EP - 168
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -