Roles of A- and D-type K channels in EPSP integration at a model dendrite

Hiroshi Takagi*, Ryo Sato, Masaya Mori, Etsuro Ito, Hideo Suzuki

*この研究の対応する著者

研究成果: Article査読

8 被引用数 (Scopus)

抄録

We examined the roles of A- and D-type K channels in the integration of EPSPs, particularly EPSP reduction, in a model dendrite using a computer simulation program (NEURON), instead of conventional electrophysiological methods which present technical difficulties. We obtained two important results: (1) KD channels play a crucial role in every synaptic input event, and (2) KA channels affect reduction of the second EPSP only when the second synaptic input is applied with a short interval (≤100 ms). These results suggest that KD channels, which have not yet been analyzed experimentally, play a major role in synaptic integration in dendrites by altering their cable properties.

本文言語English
ページ(範囲)165-168
ページ数4
ジャーナルNeuroscience Letters
254
3
DOI
出版ステータスPublished - 1998 10月 2
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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