Roles of the pontine dorsomedial tegmentum and midbrain central gray in regulating female rat sexual behaviors: Effects of p-chlorophenylalanine

Korehito Yamanouchi, Yumiko Nakano, Yasumasa Arai*

*この研究の対応する著者

    研究成果査読

    10 被引用数 (Scopus)

    抄録

    Lesions in the midbrain dorsal central gray (MCGL) markedly suppressed both lordosis and soliciting behavior in estradiol benzoate-progesterone (EB-P)-primed castrated female rats. Similarly, the pontine dorsomedial tegmental lesions (PDMTL) caused a severe loss of lordosis behavior. However, the PDMTL females while demonstrating no lordotic response displayed ear-wiggling. These results suggest that the midbrain dorsal central gray plays an important role in regulation of both lordosis and soliciting behaviors. In contrast, the pontine dorsomedial tegmentum appears to participate in regulating the neural mechanism for lordosis only and not for soliciting behavior. Two weeks later prior to a second test, approximately half of the MCGL and PDMTL females that had shown no lordosis in the first test, were injected with p-chlorophenylalanine (PCPA) and primed with EB-P. PCPA significantly increased the lordotic activity of EB-P-primed MCGL females, whereas it failed to potentiate a lordotic response in the PDMTL females. Since PCPA effectively facilitated the display of lordosis in the absence of the neural substrate of the midbrain central gray, this neural structure may not be the minimally necessary component of the neural circuitry regulating the display of lordosis behavior. On the other hand, the pontine dorsomedial tegmentum may be a neural substrate more closely related with the descending pathway controlling the expression of lordosis.

    本文言語English
    ページ(範囲)381-385
    ページ数5
    ジャーナルBrain Research Bulletin
    25
    3
    DOI
    出版ステータスPublished - 1990

    ASJC Scopus subject areas

    • 神経科学(全般)

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