Rotation of F1-ATPase: How an ATP-driven molecular machine may work

Kazuhiko Kinosita*, Kengo Adachi, Hiroyasu Itoh

*この研究の対応する著者

研究成果査読

158 被引用数 (Scopus)

抄録

F1-ATPase is a rotary motor made of a single protein molecule. Its rotation is driven by free energy obtained by ATP hydrolysis. In vivo, another motor, F0, presumably rotates the F1 motor in the reverse direction, reversing also the chemical reaction in F1 to let it synthesize ATP. Here we attempt to answer two related questions, How is free energy obtained by ATP hydrolysis converted to the mechanical work of rotation, and how is mechanical work done on F1 converted to free energy to produce ATP? After summarizing single-molecule observations of F1 rotation, we introduce a toy model and discuss its free-energy diagrams to possibly answer the above questions. We also discuss the efficiency of molecular motors in general.

本文言語English
ページ(範囲)245-268
ページ数24
ジャーナルAnnual Review of Biophysics and Biomolecular Structure
33
DOI
出版ステータスPublished - 2004
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学

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