TY - JOUR
T1 - Salivary 3-methoxy-4-hydroxyphenylglycol increases after awakening in healthy young adults
AU - Sugaya, Nagisa
AU - Izawa, Shuhei
AU - Yamamoto, Ryuichiro
AU - Ogawa, Namiko
AU - Yajima, Jumpei
AU - Okamura, Hisayoshi
AU - Horiuchi, Satoshi
AU - Tsuda, Akira
AU - Nomura, Shinobu
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30min after awakening to determine MHPG and cortisol. Ambulatory electrocardiograms were obtained to assess heart rate, cardiac sympathetic index (CSI), and cardiac vagal index (CVI) before and after awakening. MHPG levels increased significantly during the first 30min after awakening. Similarly, cortisol, heart rate, and CSI increased during the 30min after awakening, but changes in MHPG did not correlate with changes in cortisol, heart rate, CSI, and CVI during that period. This study demonstrated that salivary MHPG levels increase after awakening, in common with cortisol, heart rate, and cardiac sympathetic activity.
AB - Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30min after awakening to determine MHPG and cortisol. Ambulatory electrocardiograms were obtained to assess heart rate, cardiac sympathetic index (CSI), and cardiac vagal index (CVI) before and after awakening. MHPG levels increased significantly during the first 30min after awakening. Similarly, cortisol, heart rate, and CSI increased during the 30min after awakening, but changes in MHPG did not correlate with changes in cortisol, heart rate, CSI, and CVI during that period. This study demonstrated that salivary MHPG levels increase after awakening, in common with cortisol, heart rate, and cardiac sympathetic activity.
KW - Awakening
KW - Central noradrenergic metabolism
KW - MHPG
KW - Saliva
UR - http://www.scopus.com/inward/record.url?scp=84922821041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922821041&partnerID=8YFLogxK
U2 - 10.1111/psyp.12330
DO - 10.1111/psyp.12330
M3 - Article
C2 - 25220890
AN - SCOPUS:84922821041
VL - 52
SP - 425
EP - 428
JO - Psychophysiology
JF - Psychophysiology
SN - 0048-5772
IS - 3
ER -