Sarcomere imaging by quantum dots for the study of cardiac muscle physiology

Fuyu Kobirumaki-Shimozawa, Kotaro Oyama, Takahiro Serizawa, Akari Mizuno, Tatsuya Kagemoto, Togo Shimozawa, Shin'Ichi Ishiwata, Satoshi Kurihara, Norio Fukuda*

*この研究の対応する著者

研究成果: Article査読

6 被引用数 (Scopus)

抄録

We here review the use of quantum dots (QDs) for the imaging of sarcomeric movements in cardiac muscle. QDs are fluorescence substances (CdSe) that absorb photons and reemit photons at a different wavelength (depending on the size of the particle); they are efficient in generating long-lasting, narrow symmetric emission profiles, and hence useful in various types of imaging studies. Recently, we developed a novel system in which the length of a particular, single sarcomere in cardiomyocytes can be measured at ∼30nm precision. Moreover, our system enables accurate measurement of sarcomere length in the isolated heart. We propose that QDs are the ideal tool for the study of sarcomere dynamics during excitation-contraction coupling in healthy and diseased cardiac muscle.

本文言語English
論文番号313814
ジャーナルJournal of Biomedicine and Biotechnology
2012
DOI
出版ステータスPublished - 2012
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分子医療
  • 遺伝学
  • 分子生物学
  • 健康、毒物学および変異誘発
  • 医学(全般)

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