Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived Streptomyces

Kantinan Leetanasaksakul, Wilaiwan Koomsiri, Takuya Suga, Hirotaka Matsuo, Rei Hokari, Pakorn Wattana-Amorn, Yō Ko Takahashi, Kazuro Shiomi, Takuji Nakashima, Yuki Inahashi, Arinthip Thamchaipenet*

*この研究の対応する著者

研究成果: Review article査読

抄録

Sattahipmycin was isolated from the mycelium of marine-derived Streptomyces sp. GKU 257-1 by following the antibiofilm activity against E. coli NBRC 3972 throughout the purification steps. The structure of sattahipmycin was determined to be a new polycyclic xanthone related to xantholipin but lacking a dioxymethylene and a chlorinated carbon. This compound showed activity toward Gram-positive bacteria and Plasmodium falciparum, antibiofilm formation of Escherichia coli, and cytotoxicity to human cancer cell lines. Using genome sequence data, a biosynthetic pathway leading to sattahipmycin has been proposed involving an uncharacterized type II polyketide synthase biosynthetic gene cluster.

本文言語English
ページ(範囲)1211-1217
ページ数7
ジャーナルJournal of Natural Products
85
5
DOI
出版ステータスPublished - 2022 5月 27
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

フィンガープリント

「Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived Streptomyces」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル