Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei

Kentaro Takada, Taisuke Uehara, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani*

*この研究の対応する著者

研究成果: Article査読

94 被引用数 (Scopus)

抄録

Three new α-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C28 fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit α-glucosidase with IC50 values of 48-170 nM.

本文言語English
ページ(範囲)187-193
ページ数7
ジャーナルJournal of the American Chemical Society
126
1
出版ステータスPublished - 2004 1月 14
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

フィンガープリント

「Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル