Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei

Kentaro Takada, Taisuke Uehara, Youichi Nakao, Shigeki Matsunaga, Rob W M Van Soest, Nobuhiro Fusetani

研究成果: Article

78 引用 (Scopus)

抄録

Three new α-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C28 fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit α-glucosidase with IC50 values of 48-170 nM.

元の言語English
ページ(範囲)187-193
ページ数7
ジャーナルJournal of the American Chemical Society
126
発行部数1
出版物ステータスPublished - 2004 1 14
外部発表Yes

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Glucosidases
Porifera
Degradation
Alkaloids
Stereochemistry
Fatty acids
Spectrum analysis
Inhibitory Concentration 50
Amino acids
Fatty Acids
Amino Acids
isoquinoline

ASJC Scopus subject areas

  • Chemistry(all)

これを引用

Takada, K., Uehara, T., Nakao, Y., Matsunaga, S., Van Soest, R. W. M., & Fusetani, N. (2004). Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei. Journal of the American Chemical Society, 126(1), 187-193.

Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei. / Takada, Kentaro; Uehara, Taisuke; Nakao, Youichi; Matsunaga, Shigeki; Van Soest, Rob W M; Fusetani, Nobuhiro.

:: Journal of the American Chemical Society, 巻 126, 番号 1, 14.01.2004, p. 187-193.

研究成果: Article

Takada, K, Uehara, T, Nakao, Y, Matsunaga, S, Van Soest, RWM & Fusetani, N 2004, 'Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei', Journal of the American Chemical Society, 巻. 126, 番号 1, pp. 187-193.
Takada, Kentaro ; Uehara, Taisuke ; Nakao, Youichi ; Matsunaga, Shigeki ; Van Soest, Rob W M ; Fusetani, Nobuhiro. / Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei. :: Journal of the American Chemical Society. 2004 ; 巻 126, 番号 1. pp. 187-193.
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