Screening for sulfur compounds by molybdenum-catalyzed oxidation combined with liquid chromatography-mass spectrometry

Hirotaka Matsuo*, Yu Hanamure, Rei Miyano, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The molybdenum (Mo)-catalyzed oxidation of sulfide under neutral conditions yields sulfone. This reaction proceeds more smoothly than olefin epoxidation and primary or secondary alcohol oxidation. In this study, Mo-catalyzed oxidation was used to screen for sulfur compounds (named “MoS-screening”) in microbial broths by liquid chromatography-mass spectrometry (LC/MS). To demonstrate proof-of-concept, known sulfur microbial compounds were successfully identified from a mixture of non-sulfur microbial compounds as sulfinyl or sulfonyl products of Mo-catalyzed oxidation. Then our MoS-screening method was used to screen 300 samples of microbial broth for sulfur compounds. One of the identified compounds was a kitasetaline-containing N-acetyl cysteine moiety produced by an actinomycete strain. These results demonstrate the potential of MoS-screening in the search for new sulfur compounds from microbial sources.

本文言語English
論文番号240
ジャーナルMolecules
25
2
DOI
出版ステータスPublished - 2020
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 化学(その他)
  • 分子医療
  • 薬科学
  • 創薬
  • 物理化学および理論化学
  • 有機化学

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