抄録
Culture supernatants of enteric bacteria isolated from the gastrointestinal tracts of two marine fishes were screened for the production of immunosuppressive substances. At least 50% of the 60 bacterial isolates tested were found to produce immunosuppressants that significantly inhibited the induction of cytotoxic T cells (CTL) in vitro. The strains that secreted the highest suppressive activity was identified as Aeromonas caviae. The immunosuppressive substance purified from the A. caviae culture supernatant was a polysaccharide with a molecular weight of about 70 kDa that contained mannose : glucose (4:1). This polysaccharide did not show nonspecific cytotoxicity, and was found to inhibit the proliferation and differentiation of CD8-positive CTL.
本文言語 | English |
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ページ(範囲) | 117-119 |
ページ数 | 3 |
ジャーナル | Journal of Fermentation and Bioengineering |
巻 | 85 |
号 | 1 |
DOI | |
出版ステータス | Published - 1998 |
外部発表 | はい |
ASJC Scopus subject areas
- バイオテクノロジー
- 応用微生物学とバイオテクノロジー