Seasonal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts

Shogo Haraguchi, Masahiro Matsunaga, Teppei Koyama, Jean Luc Do Rego, Kazuyoshi Tsutsui

    研究成果: Conference contribution

    10 被引用数 (Scopus)

    抄録

    We recently found that the newt brain actively produces 7α-hydroxypregnenolone, a novel amphibian neurosteroid stimulating locomotor activity. It is well known that locomotor activity of male newts increases during the breeding period. To understand the physiological role of 7α-hydroxypregnenolone, we investigated seasonal changes in 7α-hydroxypregnenolone synthesis in the brain of male newts. Interestingly, 7α-hydroxypregnenolone synthesis in the brain showed marked changes during the annual breeding cycle, with a maximal level in the breeding period when locomotor activity of male newts increases. These results suggest that 7α-hydroxypregnenolone induces seasonal locomotor changes in male newts.

    本文言語English
    ホスト出版物のタイトルAnnals of the New York Academy of Sciences
    ページ410-413
    ページ数4
    1163
    DOI
    出版ステータスPublished - 2009 4

    出版物シリーズ

    名前Annals of the New York Academy of Sciences
    1163
    ISSN(印刷版)00778923
    ISSN(電子版)17496632

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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