TY - JOUR
T1 - Sedentary behavior and estimated nephron number in middle-aged and older adults with or without chronic kidney disease
AU - Kosaki, Keisei
AU - Takahashi, Kanako
AU - Matsui, Masahiro
AU - Yoshioka, Masaki
AU - Mori, Shoya
AU - Nishitani, Natsumi
AU - Shibata, Ai
AU - Saito, Chie
AU - Kuro-o, Makoto
AU - Yamagata, Kunihiro
AU - Oka, Koichiro
AU - Maeda, Seiji
N1 - Funding Information:
We thank each of the study participants for their effort and time contributing to the study. Also, the authors are grateful to the members of our laboratory (University of Tsukuba) and Ms. Michiru Hotta (University of Tsukuba) for their technical assistance. This work was supported in part by a Grant-in-Aid for Scientific Research KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology, Japan (grant number 19H03995) and MEXT Leading Initiative for Excellent Young Researchers Grant Number JPMXS0320200234. M.M. M.Y. S.M. were recipients of a Grant-in-Aid for Research Fellowships of Japan Society for the Promotion of Science for Young Scientists (grant number 20J20892, 21J10316, 21J10952 respectively). None.
Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology , Japan (grant number 19H03995 ) and MEXT Leading Initiative for Excellent Young Researchers Grant Number JPMXS0320200234 . M.M., M.Y., S.M. were recipients of a Grant-in-Aid for Research Fellowships of Japan Society for the Promotion of Science for Young Scientists (grant number 20J20892, 21J10316, 21J10952 respectively).
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/10/15
Y1 - 2021/10/15
N2 - Background: Excessive sedentary behavior may contribute to the pathogenesis of chronic kidney disease (CKD). The nephron index is a novel methodology for non-invasively estimating the number of functional nephrons, under the assumption that serum fibroblast growth factor 23 (FGF23) concentrations should correlate with phosphate excretion per nephron. The purpose of this study was to investigate the cross-sectional associations between daily sedentary time and the nephron index in middle-aged and older adults with or without CKD. Methods: The daily time spent in sedentary behavior was assessed using a tri-axial accelerometer in 294 participants (182 non-CKD adults and 112 CKD patients). The nephron index value was calculated by measuring blood and spot urine phosphate and creatinine, together with serum FGF23 concentrations and estimated glomerular filtration rate. Results: We observed that advancing age and CKD were associated with a progressive decrease in the nephron index value. Additionally, CKD patients with more sedentary time also had a greater nephron index decrease compared to those with less sedentary time (P < 0.05). Multiple linear regression analysis confirmed the independent association between sedentary time and the nephron index after adjusting for age, sex, presence of CKD, overweight/obesity, medication use, and total wear time (β = −0.13, P = 0.035). Conclusions: These cross-sectional findings suggest that age- or CKD-related decreases in the estimated nephron number (that is, the nephron index) may be accelerated by increased sedentary behavior.
AB - Background: Excessive sedentary behavior may contribute to the pathogenesis of chronic kidney disease (CKD). The nephron index is a novel methodology for non-invasively estimating the number of functional nephrons, under the assumption that serum fibroblast growth factor 23 (FGF23) concentrations should correlate with phosphate excretion per nephron. The purpose of this study was to investigate the cross-sectional associations between daily sedentary time and the nephron index in middle-aged and older adults with or without CKD. Methods: The daily time spent in sedentary behavior was assessed using a tri-axial accelerometer in 294 participants (182 non-CKD adults and 112 CKD patients). The nephron index value was calculated by measuring blood and spot urine phosphate and creatinine, together with serum FGF23 concentrations and estimated glomerular filtration rate. Results: We observed that advancing age and CKD were associated with a progressive decrease in the nephron index value. Additionally, CKD patients with more sedentary time also had a greater nephron index decrease compared to those with less sedentary time (P < 0.05). Multiple linear regression analysis confirmed the independent association between sedentary time and the nephron index after adjusting for age, sex, presence of CKD, overweight/obesity, medication use, and total wear time (β = −0.13, P = 0.035). Conclusions: These cross-sectional findings suggest that age- or CKD-related decreases in the estimated nephron number (that is, the nephron index) may be accelerated by increased sedentary behavior.
KW - Fibroblast growth factor 23
KW - Functional nephron number
KW - Phosphate
KW - Sedentary time
UR - http://www.scopus.com/inward/record.url?scp=85113451391&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85113451391&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2021.111531
DO - 10.1016/j.exger.2021.111531
M3 - Article
C2 - 34450233
AN - SCOPUS:85113451391
VL - 154
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
M1 - 111531
ER -