Self-calibrated fluorescent thermometer nanoparticles enable in vivo micro thermography in milimeter scale living animals

Ferdinandus, Satoshi Arai, Shin'Ichi Ishiwata, Madoka Suzuki, Hirotaka Sato

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

We have developed a fluorescent nanoparticle thermometer capable of mapping out the temperature distributions in small animals with higher spatial resolution than conventional infrared thermography. To acquire the fluorescence intensity change solely owing to the temperature shift, we encapsulated both the thermo-sensitive dye and the thermo-insensitive (reference) dye into the nanoparticles. The nanoparticle thermometer exhibited a significantly high thermo-sensitivity of 3.6 %/°C, and could be orally dosed into fruit fly larvae so as to stably measure the temperature distributions in the animals. This thermal-microscopy system could provide a powerful experimental paradigm to illuminate physiological functions and activities in small living organisms.

本文言語English
ホスト出版物のタイトル2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
出版社Institute of Electrical and Electronics Engineers Inc.
ページ2228-2231
ページ数4
ISBN(印刷版)9781479989553
DOI
出版ステータスPublished - 2015 8 5
イベント18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States
継続期間: 2015 6 212015 6 25

Other

Other18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
CountryUnited States
CityAnchorage
Period15/6/2115/6/25

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

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