Self-complementary peptides for the formation of collagen-like triple helical supramolecules

Takaki Koide*, Daisuke L. Homma, Shinichi Asada, Kouki Kitagawa

*この研究の対応する著者

研究成果: Article査読

65 被引用数 (Scopus)

抄録

Collagen is acknowledged as one of the most prominent biomaterials on account of its high biocompatibility and biostability. The development of artificial collagens to replace the animal-derived collagens presents a challenge in the formation of safer and highly functionalized biomaterials. Here, a novel peptide-based system for obtaining collagen-like supramolecules via a spontaneous self-assembling process is described. The designed collagen-like peptides are self-complementary trimers in which each of the 24-mer peptide strands is tethered by two cystine knots forming a staggered arrangement. Their self-assembling ability in aqueous solution was analyzed by circular dichroism, ultrafiltration, and laser diffraction particle size estimation. The obtained results indicate that the staggered trimers form large supramolecular architectures through intermolecular triple helix-formation.

本文言語English
ページ(範囲)5230-5233
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
15
23
DOI
出版ステータスPublished - 2005 12月 1
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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