@article{3500dcb043a64025a4eda0f18b6d1815,
title = "Self-disproportionation of enantiomers of thalidomide and its fluorinated analogue via gravity-driven achiral chromatography: Mechanistic rationale and implications",
abstract = "We report on the self-disproportionation of enantiomers (SDE) of non-racemic thalidomide (1) and 3′-fluorothalidomide (2) under the conditions of gravity-driven achiral silica-gel chromatography. The presence of a fluorine atom on the chiral center dramatically alters the structure and polarity of 1 and 2, resulting in the opposite SDE profile on silica-gel.",
author = "Mayaka Maeno and Etsuko Tokunaga and Takeshi Yamamoto and Toshiya Suzuki and Yoshiyuki Ogino and Emi Ito and Motoo Shiro and Toru Asahi and Norio Shibata",
note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",
year = "2015",
month = feb,
day = "1",
doi = "10.1039/c4sc03047h",
language = "English",
volume = "6",
pages = "1043--1048",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "2",
}