Self-oscillating gel as novel biomimetic materials

Ryo Yoshida*, Takamasa Sakai, Yusuke Hara, Shingo Maeda, Shuji Hashimoto, Daisuke Suzuki, Yoko Murase


    研究成果: Article査読

    60 被引用数 (Scopus)


    Stimuli-responsive polymers and their application to biomaterials have been widely studied. On the other hand, as a novel biomimetic polymer, we have been studying the polymer with an autonomous self-oscillating function by utilizing oscillating chemical reactions. So far, we succeeded in developing a novel self-oscillating polymer and gels by utilizing the oscillating reaction, called the Belousov-Zhabotinsky (BZ) reaction, which is recognized as a chemical model for understanding several autonomous phenomena in biological systems. The self-oscillating polymer is composed of poly(N-isopropylacrylamide) (PNIPAAm) network in which the catalyst for the BZ reaction is covalently immobilized. Under the coexistence of the reactants, the polymer undergoes spontaneous cyclic soluble-insoluble changes or swelling-deswelling changes (in the case of gel) without any on-off switching of external stimuli. In this paper, our recent studies on the self-oscillating polymer gels and the design of functional material systems using the polymer are summarized.

    ジャーナルJournal of Controlled Release
    出版ステータスPublished - 2009 12月 16

    ASJC Scopus subject areas

    • 薬科学


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