抄録
Disturbed circadian rhythmicity is associated with human diseases such as sleep and mood disorders. However, study of human endogenous circadian rhythm is laborious and time-consuming, which hampers the elucidation of diseases. It has been reported that peripheral tissues exhibit circadian rhythmicity as the suprachiasmatic nucleus-the center of the biological clock. We tried to study human circadian rhythm using cultured peripheral blood mononuclear cells (PBMCs) obtained from a single collection of venous blood. Activated human PBMCs showed self-sustained circadian rhythm of clock gene expression, which indicates that they are useful for investigating human endogenous circadian rhythm.
本文言語 | English |
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ページ(範囲) | 223-227 |
ページ数 | 5 |
ジャーナル | Neuroscience Research |
巻 | 66 |
号 | 2 |
DOI | |
出版ステータス | Published - 2010 2月 |
ASJC Scopus subject areas
- 神経科学(全般)