Self-sustained circadian rhythm in cultured human mononuclear cells isolated from peripheral blood

Takashi Ebisawa*, Kahori Numazawa, Hiroko Shimada, Hiroyuki Izutsu, Tsukasa Sasaki, Nobumasa Kato, Katsushi Tokunaga, Akio Mori, Ken ichi Honma, Sato Honma, Shigenobu Shibata

*この研究の対応する著者

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Disturbed circadian rhythmicity is associated with human diseases such as sleep and mood disorders. However, study of human endogenous circadian rhythm is laborious and time-consuming, which hampers the elucidation of diseases. It has been reported that peripheral tissues exhibit circadian rhythmicity as the suprachiasmatic nucleus-the center of the biological clock. We tried to study human circadian rhythm using cultured peripheral blood mononuclear cells (PBMCs) obtained from a single collection of venous blood. Activated human PBMCs showed self-sustained circadian rhythm of clock gene expression, which indicates that they are useful for investigating human endogenous circadian rhythm.

本文言語English
ページ(範囲)223-227
ページ数5
ジャーナルNeuroscience Research
66
2
DOI
出版ステータスPublished - 2010 2月

ASJC Scopus subject areas

  • 神経科学(全般)

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