Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Takayuki Matsumura, Tadayoshi Ikebe, Koji Arikawa, Masahito Hosokawa, Michio Aiko, Aoi Iguchi, Ikuko Togashi, Sayaka Kai, Sakiko Ohara, Naoya Ohara, Makoto Ohnishi, Haruo Watanabe, Kazuo Kobayashi, Haruko Takeyama, Sho Yamasaki, Yoshimasa Takahashi, Manabu Ato

研究成果: Article

1 引用 (Scopus)

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Matsumura et al. show that γIMCs sequentially sense group A Streptococcus (GAS) through TLR2 and Mincle. Specifically, TLR2-triggered production of IL-6 functions as an intermediate that amplifies Mincle expression to maximize host protection through IFN-γ production. The sequential sensing is a distinct feature in γIMCs following severe invasive GAS infection.

元の言語English
ページ(範囲)561-571.e6
ジャーナルCell Reports
27
発行部数2
DOI
出版物ステータスPublished - 2019 4 9

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Matsumura, T., Ikebe, T., Arikawa, K., Hosokawa, M., Aiko, M., Iguchi, A., Togashi, I., Kai, S., Ohara, S., Ohara, N., Ohnishi, M., Watanabe, H., Kobayashi, K., Takeyama, H., Yamasaki, S., Takahashi, Y., & Ato, M. (2019). Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice. Cell Reports, 27(2), 561-571.e6. https://doi.org/10.1016/j.celrep.2019.03.056