抄録
1. The effect of serotonin (5-hydroxytryptamine; 5-HT) on the induction of long-term potentiation (LTP) in rat visual cortex was investigated by using slice preparations in vitro. 2. Bath application of 5-HT (0.1-10 μM) did not affect the baseline synaptic potentials evoked by single-pulse test stimulation, but inhibited the induction of LTP in a concentration-dependent manner. 3. The effect of 5-HT was blocked by the 5-HTi receptor antagonist pindolol or the 5-HT2.7 receptor antagonist ritanserin, but not by the 5-HT3,4 receptor antagonist MDL72222. 4. These results suggest that 5-HT plays a role in suppressing the induction of LTP in the rat visual cortex.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 983-997 |
| ページ数 | 15 |
| ジャーナル | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| 巻 | 22 |
| 号 | 6 |
| 出版ステータス | Published - 1998 8月 1 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 薬理学
- 生物学的精神医学