Serotonin transporter gene and inhibition of conflicting emotional information

Ai Koizumi, Norimichi Kitagawa, Miho Kitamura, Hirohito M. Kondo, Takao Sato, Makio Kashino

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Genetic variation of the serotonin-transporter-linked promoter region has been reported to be associated with susceptibility to mood disorders. However, little is known about the behavioral characteristics that mediate this genetic variation and susceptibility to depression. We examined whether the serotonin-transporter genotype modulates inhibition of facial expressions and emotional words in the emotional 'face-word' Stroop task. Although negative word distractors interfered with the valence identification of positive faces among carriers of two short alleles, positive word distractors interfered with that of negative faces among carriers of one or two long alleles. We discuss a possible role of the reduced inhibitory control over semantic negative information in carriers of two short alleles in the risk of developing depressive mental state.

本文言語English
ページ(範囲)422-426
ページ数5
ジャーナルNeuroReport
21
6
DOI
出版ステータスPublished - 2010
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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