Sex and regional differences in decrease of serotonin-immunoreactive cells by parachlorophenylalanine in rat raphe nuclei

Hiroyuki Ito, Korehito Yamanouchi*

*この研究の対応する著者

研究成果: Article査読

4 被引用数 (Scopus)

抄録

To determine sex and regional differences in the properties of serotonin (5-HT) neurons of the raphe nuclei, the responsiveness to parachlorophenylalanine (PCPA) of 5-HT neurons in the dorsal and median raphe nuclei (DR and MR) and the nucleus raphe magnus (RMg) was analyzed by counting 5-HT-immunoreactive (5-HT-ir) cells. Gonadectomized male (OCX) and female (OVX) rats were treated with 100. mg/kg b.wt PCPA or saline daily for 4 days. The brains were removed and fixed one day after the last injection. Frozen sections were stained with serotonin antibody and the numbers of 5-HT-ir cells in the raphe nuclei were counted. As a result, in female rats, the densities of 5-HT-ir cells in these 3 raphe nuclei were almost the same when compared the PCPA-treated and saline-treated groups. On the other hand, in male rats, the densities of 5-HT-ir cells in the DR and MR of PCPA-treated rats were lower than in saline-treated rats. In the male RMg, no difference was seen. These results suggest that responsiveness of 5-HT neurons to PCPA in the DR and MR, but not in the RMg, were sexually dimorphic.

本文言語English
ページ(範囲)33-39
ページ数7
ジャーナルNeuroscience Research
67
1
DOI
出版ステータスPublished - 2010 5

ASJC Scopus subject areas

  • 神経科学(全般)

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