Sex-dependent developmental change of rat liver cytosolic alcohol dehydrogenase activity

Saori Harada, Kaoru Tachiyashiki, Kazuhiko Imaizumi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Rat liver cytosolic alcohol dehydrogenase (ADH) is the principal enzyme which catalyzes the oxidation of ethanol. ADH activity is known to be significantly higher in females than in males. However, the precise mechanism of the sex-difference in ADH activity is uncertain. Recently, we have shown that the inhibitory action of androgen and the slight facilitatory actions of progestin and estrogen are involved in the mechanism of sex-difference in adult rat liver ADH activity. In the present study, we studied the difference of the postnatal developmental changes of ADH activity between males and females. ADH activity increased rapidly after birth up to about 12 d of age, and was not different in the two sexes. In female rats, ADH activity peaked at about 30 d of age and then increased gradually to plateau levels. However, the ADH activity of male rats fell markedly between 30 and 45 d old, and the reduced enzyme activity was observed until 104 d old. In conclusion, the ADH activity of male rats fell between 30 and 45 d after birth. At the ages over the turning point, the ADH activity was significantly lower in male than in female rats.

本文言語English
ページ(範囲)49-52
ページ数4
ジャーナルJournal of Nutritional Science and Vitaminology
46
1
出版ステータスPublished - 2000
外部発表はい

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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